PADI6: What we know about the elusive fifth member of the peptidyl arginine deiminase family
JPC Williams, LJ Walport - Philosophical Transactions of …, 2023 - royalsocietypublishing.org
… oocyte and early embryo, PADI6 is crucial for early embryonic development and female fertility
… cell lines, potentially affecting cellular cytoskeletal dynamics and cell migration. Together …
… cell lines, potentially affecting cellular cytoskeletal dynamics and cell migration. Together …
Peptidylarginine deiminase enzymes and citrullinated proteins in female reproductive physiology and associated diseases
AO Christensen, G Li, CH Young, B Snow… - Biology of …, 2022 - academic.oup.com
… KO mice are infertile, while males are fertile [93]. A similar … complex in the oocyte cytoplasm,
which is required for early … In non-reproductive models, the citrullination of cytoskeletal …
which is required for early … In non-reproductive models, the citrullination of cytoskeletal …
[HTML][HTML] Two novel mutations in PADI6 and TLE6 genes cause female infertility due to arrest in embryonic development
J Liu, Z Tan, J He, T Jin, Y Han, L Hu… - Journal of Assisted …, 2021 - Springer
… mutations in the peptidylarginine deiminase type VI (PADI6) … in mammalian oocytes and
early embryos, essential for … cofilin controlled the formation of the actin cytoskeleton which …
early embryos, essential for … cofilin controlled the formation of the actin cytoskeleton which …
Proteomic analysis of mouse ovaries during the prepubertal stages
J Xiong, M Wu, Q Zhang, C Zhang, G Xiong, L Ma… - Experimental cell …, 2019 - Elsevier
… stage are important for normal ovarian function and fertility, and a … Peptidylarginine deiminase
6 (PADI6) is an enzyme that is … in oocytes results in dispersal of the cytoskeletal sheets in …
6 (PADI6) is an enzyme that is … in oocytes results in dispersal of the cytoskeletal sheets in …
[HTML][HTML] Novel homozygous PADI6 variants in infertile females with early embryonic arrest
Y Xu, R Wang, Z Pang, Z Wei, L Sun, S Li… - Frontiers in Cell and …, 2022 - frontiersin.org
… oocytes and early embryos based on our in-house database; 6) genes previously reported
to affect female fertility … PADI6 is a member of the peptidylarginine deiminase (PADI) family, a …
to affect female fertility … PADI6 is a member of the peptidylarginine deiminase (PADI) family, a …
[HTML][HTML] Padi6 expression patterns in buffalo oocytes and preimplantation embryos
Q Sun, Y Yang, Y Zhang, D Chen, H Zheng… - Animal …, 2024 - SciELO Brasil
… Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and
female fertility… cytoskeletal sheet formation and female fertility. Mol Cell Endocrinol. 2007;273(…
female fertility… cytoskeletal sheet formation and female fertility. Mol Cell Endocrinol. 2007;273(…
[PDF][PDF] Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices
… were proposed to be oocyte-specific in… oocyte-specific proteins that are essential for the
formation of cytoplasmic lattices. These proteins were PADI6 (peptidylarginine deiminase 6) and …
formation of cytoplasmic lattices. These proteins were PADI6 (peptidylarginine deiminase 6) and …
Novel Macrocyclic Peptidylarginine Deiminase Type 4 (PAD4) Inhibitors
RW Sabnis - ACS Medicinal Chemistry Letters, 2022 - ACS Publications
… PAD6 is thought to be the only catalytically inactive PAD and is expressed mainly in oocytes…
to be involved in oocyte cytoskeletal sheet formation and female fertility. PAD1 and PAD3 …
to be involved in oocyte cytoskeletal sheet formation and female fertility. PAD1 and PAD3 …
Insights into peptidylarginine deiminase expression and citrullination pathways
K Yu, P Proost - Trends in Cell Biology, 2022 - cell.com
… Therefore, the latest insights reveal how PAD activity affects cytoskeletal organization and
… Citrullination should no longer be considered as a rare PTM, but as an important regulatory …
… Citrullination should no longer be considered as a rare PTM, but as an important regulatory …
Subcortical maternal complex (SCMC) expression during folliculogenesis is affected by oocyte donor age in sheep
D Bebbere, A Abazari-Kia, S Nieddu… - Journal of assisted …, 2020 - Springer
… in female fertility is largely ascribable to the decrease in oocyte … It regulates F-actin cytoskeleton
via Cofilin in mouse zygotes, … (OOEP/FLOPED), peptidyl arginine deiminase 6 (PADI6), …
via Cofilin in mouse zygotes, … (OOEP/FLOPED), peptidyl arginine deiminase 6 (PADI6), …